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September 4, 2025Open Access

Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

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Key Points

Deletion of TRAP1 drives glutamine addiction in tumor cells, enhancing metabolic vulnerability.
13C Gln tracing data indicates significant metabolic changes in both WT and TRAP1 KO HCT116 cells.
Observational analysis assessed the impact of TRAP1 deletion on the function of the cys/glu antiporter.
Findings support that targeting TRAP1 may offer new strategies for addressing glutamine addiction in cancers.

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Implication

Analysis reveals destabilization of the cys/glu antiporter in TRAP1 KO tumor cells, impacting glutamine metabolism.

Abstract

This table has 13C Gln tracing data for WT and TRAP1 KO HCT116 cells

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a0615404 https://doi.org/10.1158/1541-7786.30050544

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025