⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 4, 2025Open Access

Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

View Full Paper

Ask AI

Bookmark

Share

Key Points

TRAP1 deletion promotes glutamine addiction in tumor cells by destabilizing the SLC7A11/xCT transporter.
Data shows metabolic differences between WT and TRAP1 KO PC3 cells through 13C Glc tracing.
Analysis utilizes 13C labeling to investigate cellular metabolism in cancer models, revealing critical pathways.
Findings suggest that targeting the cys/glu antiporter may provide therapeutic avenues for tumor treatment.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Table presents 13C Glc tracing data for WT and TRAP1 KO PC3 cells, indicating altered metabolic pathways.

Abstract

This table has 13C Glc tracing data for WT and TRAP1 KO PC3 cells

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061491d https://doi.org/10.1158/1541-7786.30050550

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary Figure S5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025