Supplemental Table S1 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Joanna Poźniak; Niccolò Roda; Ewout Landeloos; Asier Antoranz; Yannick Van Herck; Amber De Visscher; Philip Georg Demaerel; Lukas Vanwynsberghe; Jeroen Declercq; Christos Gkemisis; Greet Bervoets; No‐Joon Song; Ayse Bassez; Robin Browaeys; Lotte Pollaris; Francesca M. Bosisio; Veerle Boecxstaens; Yvan Saeys; Diether Lambrechts; Zihai Li; Patrick Matthys; Oliver Bechter; Jean‐Christophe Marine

doi:10.1158/2159-8290.30050748

Key Points

Cytotoxic nk cells impede treatment response in melanoma, highlighting challenges in patient management.
Patients with immune-excluded phenotype showed reduced effectiveness from checkpoint immunotherapy based on analyses.
Assessment using scRNA-seq and FLOW cytometry techniques provided insights into immune cell characteristics.
Findings indicate the need for tailored strategies addressing immune-excluded phenotypes in cancer therapy.

Implication

Observational analysis reveals negative impact of cytotoxic nk cells on checkpoint immunotherapy in melanoma, suggesting immune-excluded phenotype limits treatment effectiveness.

Abstract

Characteristics of patients for (A) scRNA-seq, (B) MILAN mIF samples, (C) FLOW cytometry of peripheral NK cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Poźniak et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148d9 https://doi.org/10.1158/2159-8290.30050748

View at Publisher

Ask AI

Bookmark

Share

Supplemental Table S1 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplemental Table S1 from Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

Keep reading

More related papers