Figure S5 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992563

Key Points

TGFβ inhibition enhances immune cell infiltration, leading to reduced metastases in Ewing Sarcoma.
Key findings indicate significant improvements in immune response following TGFβ inhibition during treatment.
Findings are based on analysis of tissue staining for CD99 and NKX2.2, reflecting immune dynamics.
Potential for combining TGFβ inhibition with radiotherapy to improve treatment outcomes in patients.

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Implication

This research shows that TGFβ inhibition during radiotherapy improves immune cell infiltration in Ewing Sarcoma, suggesting a potential therapeutic approach.

Abstract

Figure S5. Negative control tissue for CD99 and NKX2.2 staining.

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Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f876c https://doi.org/10.1158/2767-9764.29992563

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Figure S5 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

Figure S5 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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