Figure S6 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Jessica D. Daley; Elina Mukherjee; David Ferraro; A. Carolina Tufino; Nathanael G. Bailey; Shanthi Bhaskar; Nivitha Periyapatna; Ian MacFawn; Sean Hartwick; Sheryl Kunning; Cynthia S. Hinck; Tullia C. Bruno; Adam C. Olson; Linda M. McAllister‐Lucas; Andrew P. Hinck; Kristine Cooper; Riyue Bao; Anthony R. Cillo; Kelly M. Bailey

doi:10.1158/2767-9764.29992560

Key Points

TGFβ inhibition significantly enhances immune cell infiltration, leading to decreased metastases in Ewing sarcoma.
Natural killer cells have been observed in the peripheral blood of humanized mice models, supporting immune response to therapy.
The findings indicate that combining radiotherapy with TGFβ inhibition could improve outcomes in Ewing sarcoma patients.
These strategies may provide new avenues for treatment, enhancing the effectiveness of existing therapies.

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Implication

Findings reveal that TGFβ inhibition enhances immune cell infiltration and reduces metastases in Ewing sarcoma, suggesting potential treatment strategies.

Abstract

Figure S6. Human natural killer (NK) cells are present in the peripheral blood of humanized mice.

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Daley et al. (2025) studied this question.

synapsesocial.com/papers/68c1d5e554b1d3bfb60f88b0 https://doi.org/10.1158/2767-9764.29992560

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Figure S6 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

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Implication

Abstract

Discussion

Cite This Study

Figure S6 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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