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September 9, 2025

Figure 1 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

Dong Oh Kim Eun Hye Jang Younghang Kwon Ji Hye Yoo Xiangyu Ma Ki Hoon Kim Dong Geun Hong Chung Kwon Kim Hyun Nam Jung Won Choi Geun‐Hyoung Ha Kyeung Min Joo

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Key Points

MSCs expressing CES1 and sTRAIL induced significant apoptosis in lung cancer metastases, notably decreasing tumor weight.
Tumor volume decreased remarkably in the gene-transfected treatment groups, with a mean reduction reported.
Bioluminescence imaging confirmed the therapeutic effects of CES1 and sTRAIL in controlling tumor growth.
Statistical analysis indicated significant differences across treatment groups, highlighting the efficacy of the approach.

Implication

In vivo analysis shows that MSCs expressing CES1 and sTRAIL reduce tumor volume in lung cancer, implying potential for targeted therapy.

Abstract

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa69097 https://doi.org/10.1158/2767-9764.30083908

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure 4 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
2Figure 6 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
3Figure 3 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
4Figure 7 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
5Figure 2 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025

More related papers

Figure 5 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
Data from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions2025
Mesenchymal stem cells expressing CES1 and soluble TRAIL activate CPT-11 and induce apoptosis in lung cancer brain metastatic lesions2025