Figure 2 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

Dong Oh Kim; Eun Hye Jang; Younghang Kwon; Ji Hye Yoo; Xiangyu Ma; Ki Hoon Kim; Dong Geun Hong; Chung Kwon Kim; Hyun Nam; Jung Won Choi; Geun‐Hyoung Ha; Kyeung Min Joo

doi:10.1158/2767-9764.30083905

September 9, 2025

Figure 2 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

View at Publisher

Ask AI

Bookmark

Share

Key Points

LNP-mRNA-transfected mesenchymal stem cells induced significant apoptosis in lung cancer metastatic lesions.
Average tumor volume was notably reduced in treatment groups compared to controls, confirming therapeutic potential.
In vivo experimentation involved assessing changes in body weight and tumor metrics in nude mice.
Results highlight potential new avenues for treatment of brain metastasis using modified stem cells.

Implication

In vivo analysis shows that mesenchymal stem cells expressing CES1 activate treatment in lung cancer, suggesting potential strategies for brain metastasis.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68d46ccf31b076d99fa690a6 https://doi.org/10.1158/2767-9764.30083905

View at Publisher

Ask AI

Bookmark

Share

Figure 2 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure 2 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

Keep reading

More related papers