In vivo analysis shows that MSCs expressing EGFP and TRAIL enhance CPT-11 efficacy in brain metastatic lesions, indicating potential for targeted cancer therapy.
Therapeutic tumor-homing ability of MSCs. A, Schematic representation of an in vivo experiment. B, Confirming EGFP expression in Western blot results of WJ-MSCs transfected with LNP-mRNA. C, The CLSM results depict brain cross-sections from 0 to 48 hours after ICV injection of WJ-MSCs-mRNA-EGFP into mouse brains. (Green represents Alexa Fluor 488 fluorescence, and blue represents DAPI staining). CLSM, confocal laser scanning microscope; DAPI, 4′,6-diamidino-2-phenylindole, dihydrochloride.
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Kim et al. (2025) studied this question.
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