Figure 6 from Mesenchymal Stem Cells Expressing CES1 and Soluble TRAIL Activate CPT-11 and Induce Apoptosis in Lung Cancer Brain Metastatic Lesions

Therapeutic efficacy of CES1 and sTRAIL mRNAs delivered via WJ-MSCs in a lung cancer brain metastasis model. A, Schematic overview of the in vivo experimental design. B, Western blot analysis of CES1 and FLT-3L expression in WJ-MSCs transfected with LNP-encapsulated mRNAs. C, Bioluminescence imaging of tumor-bearing mice performed using the IVIS imaging system. D, Quantification of bioluminescent signals at 14 days after H460-Luc cell injection. NS, not significant. E, Body weight monitoring of nude mice throughout the treatment period. Data are presented as the mean ± SD; n = 5 per group. P values of statistical significance are represented as *, P < 0.05; **, P < 0.001.