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September 30, 2025HLA

The HLA‐C*12:72 Allele, Confirmed by Next‐Generation Sequencing in an Indian Individual

Samir Agarwal Shikha Kumari Neha Bairagi Sachin Rana Manu Bamal

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Key Points

The hla-c*12:72 allele features a unique nonsynonymous substitution compared to hla-c*12:02:02:01.
This substitution is identified as c.312C>A occurring in exon 2, crucial for HLA classification.
Next-generation sequencing offers robust methods for validating genetic variants in diverse populations.
Understanding these alleles may enhance insights into immune response variability among individuals.

Implication

Analysis verifies hla-c*12:72 through next-generation sequencing in an individual, suggesting genetic diversity.

Abstract

The HLA‐C*12:72 allele, differs from HLA‐C*12:02:02:01 , by one nonsynonymous substitution, c.312C>A in exon 2.

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Cite This Study

Agarwal et al. (2025) studied this question.

synapsesocial.com/papers/68de68ea83cbc991d0a215fa https://doi.org/10.1111/tan.70428

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