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October 15, 2025

Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Jianpeng Yu Chen Jin Cheng Su David Moon Michael A. Sun Hong Zhang Xue Jiang Fan Zhang Nomingerel Tserentsoodol Michelle Bowie Christopher J. Pirozzi Daniel J. George Robert Wild Xia Gao David M. Ashley Yiping He Jiaoti Huang

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Key Points

MTAP-dependent purine salvage provides necessary purines to support tumor cell survival during stress.
The study indicates that purine shortage may influence cancer progression through cellular vulnerabilities.
MTAP has crucial implications for therapeutic strategies targeting tumor resilience under nutrient stress.
A better understanding of the purine supply mechanisms could lead to improved cancer treatment approaches.

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Implication

Analysis reveals the role of mtap in enhancing purine supply for tumor cells under purine shortage stress, suggesting its vital function.

Abstract

The MTAP-dependent purine salvage is a source of purine supply for cancer cells.

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Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcad6 https://doi.org/10.1158/1078-0432.30363241

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
2Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
3Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
4Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
5Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025

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Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
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Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025