Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

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October 15, 2025Open Access

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Key Points

Highlighting the vulnerabilities of tumor cells under purine shortage stress, which may lead to significant implications for cancer treatment.
The study demonstrates that DRP-104 effectively simulates DNA damage and engages the cGAS-STING pathway in the context of purine shortage.
About tumor cells, purine shortage can induce DNA damage, affecting their resilience and response to stressors, which is vital for therapeutic strategies.
This research reveals potential targets within the cGAS-STING pathway for enhancing cancer resilience treatments under nutrient stress.

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Simulation of DNA damage and activation of the cGAS-STING pathway in tumor cells under purine shortage stress.

DRP-104 simulates DNA damage and the cGAS-STING pathway.

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Yu et al. (2025) studied this question.

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