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October 15, 2025

Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Jianpeng Yu Chen Jin Cheng Su David Moon Michael A. Sun Hong Zhang Xue Jiang Fan Zhang Nomingerel Tserentsoodol Michelle Bowie Christopher J. Pirozzi Daniel J. George Robert Wild Xia Gao David M. Ashley Yiping He Jiaoti Huang

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Key Points

Purine shortage stress significantly affects resilience in tumor cells and alters their metabolic pathways.
Key evidence indicates that DRP-104 modifies purine supply, influencing tumor cell responses during stress.
Observational analysis reveals insights into the vulnerabilities of tumor cells when faced with purine metabolism disruptions.
Understanding how tumor cells cope with purine shortages may inform future treatment strategies to enhance therapeutic efficacy.

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Implication

This research finds that DRP-104 alters purine metabolism in tumor cells, suggesting new therapeutic avenues for stress response.

Abstract

DRP-104 affects purine metabolism and purine supply.

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Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb25 https://doi.org/10.1158/1078-0432.30363253

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
2Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
3Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
4Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
5Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025

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Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
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