⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 15, 2025Open Access

Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Jianpeng Yu Chen Jin Cheng Su David Moon Michael A. Sun Hong Zhang Xue Jiang Fan Zhang Nomingerel Tserentsoodol Michelle Bowie Christopher J. Pirozzi Daniel J. George Robert Wild Xia Gao David M. Ashley Yiping He Jiaoti Huang

View Full Paper

Ask AI

Bookmark

Share

Key Points

Inhibiting MTAP makes tumor cells more sensitive to DRP-104 treatments.
Key evidence shows that targeting MTAP enhances the efficacy of DRP-104 against tumor cells under purine shortage.
The approach involves evaluating the effects of MTAP inhibition in enhancing treatment responses of tumor cells.
These findings highlight the potential for improving therapeutic strategies in tumor cells facing purine shortage.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Inhibition of MTAP enhances tumor cell sensitivity to DRP-104, suggesting treatment potential under purine shortage.

Abstract

Inhibiting MTAP sensitizes tumor cells to DRP-104 treatments.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dccc5 https://doi.org/10.1158/1078-0432.30363238

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
2Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
3Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
4Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
5Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025

More related papers

Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
Data from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025