Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

J.Z. Yu; Chen Jin; Cheng Su; David Moon; Michael A. Sun; Hong Zhang; Xue Jiang; Fan Zhang; Nomingerel Tserentsoodol; Michelle Bowie; Christopher J. Pirozzi; Daniel J. George; Robert Wild; Xia Gao; David M. Ashley; Yiping He; Jiaoti Huang

doi:10.1158/1078-0432.30363235

October 15, 2025

Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

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Key Points

Treatment with DRP-104 and MTDIA alters the tumor's immune microenvironment.
Animal body weight remains unchanged despite tumor treatment with DRP-104 and MTDIA.
The impact on tumor immunity suggests potential for further exploration in therapy.
Understanding the immune microenvironment is crucial during purine shortage stress in cancer.

Implication

Observational study shows altered immune microenvironment in tumors of mice treated with DRP-104 and MTDIA, indicating potential therapeutic pathways.

Abstract

Treating tumor-bearing mice with DRP-104 in combination with MTDIA does not affect animal’s body weight but alters the tumor’s immune microenvironment.

Discussion

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Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb90 https://doi.org/10.1158/1078-0432.30363235

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Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S7 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Key Points

Implication

Abstract

Discussion

Cite This Study

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