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October 15, 2025

Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Jianpeng Yu Chen Jin Cheng Su David Moon Michael A. Sun Hong Zhang Xue Jiang Fan Zhang Nomingerel Tserentsoodol Michelle Bowie Christopher J. Pirozzi Daniel J. George Robert Wild Xia Gao David M. Ashley Yiping He Jiaoti Huang

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Key Points

Purine biosynthesis is a crucial factor influencing tumor cell behavior under stress conditions, enhancing cancer resilience.
Gene expression and functional assays provide evidence of the significant role of purine biosynthesis in prostate cancer development.
The study highlights the importance of metabolic pathways, specifically purine biosynthesis, in cancer pathogenesis.
Understanding purine metabolism may reveal potential therapeutic targets for prostate cancer treatment in the future.

Implication

Research demonstrates purine biosynthesis affects tumor cells in prostate cancer, indicating its role in disease development.

Abstract

Gene expression and functional assays implicate purine biosynthesis as a driver of prostate cancer pathogenesis.

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Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb32 https://doi.org/10.1158/1078-0432.30363247

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
2Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
3Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
4Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
5Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025

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Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025