⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 15, 2025

Supplementary Figure S1 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress

Jianpeng Yu Chen Jin Cheng Su David Moon Michael A. Sun Hong Zhang Xue Jiang Fan Zhang Nomingerel Tserentsoodol Michelle Bowie Christopher J. Pirozzi Daniel J. George Robert Wild Xia Gao David M. Ashley Yiping He Jiaoti Huang

View at Publisher

Ask AI

Bookmark

Share

Key Points

DON effectively inhibits FGAMS, reducing purine biosynthesis in tumor cells under stress.
With the lowest Ki, DON demonstrates significant potency in inhibiting this enzyme.
Detailed assessments reveal the vulnerability of tumor cells to purine shortage stress.
The findings suggest potential therapeutic strategies targeting purine metabolism in tumor treatment.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

This analysis reveals how DON inhibits FGAMS, a key enzyme in purine biosynthesis, suggesting implications for tumor cell resilience.

Abstract

DON inhibits FGAMS, a de novo purine biosynthesis enzyme, with the lowest Ki.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb48 https://doi.org/10.1158/1078-0432.30363256

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
2Supplementary Figure S5 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
3Supplementary Figure S9 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
4Supplementary Figure S3 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
5Supplementary Figure S4 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025

More related papers

Supplementary Figure S6 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
Supplementary Figure S8 from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025
Data from Resilience and Vulnerabilities of Tumor Cells under Purine Shortage Stress2025