Why the study?
Does acute disruption of fibrillar collagen via plasmin treatment decrease myocardial systolic performance in isolated papillary muscles?
Does acute disruption of fibrillar collagen via plasmin treatment decrease myocardial systolic performance in isolated papillary muscles?
Acute disruption of the fibrillar collagen network decreases myocardial systolic performance without altering individual cardiomyocyte contractility, demonstrating that fibrillar collagen is essential for transducing cardiomyocyte contraction into myocardial force.
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Hypothesis-generating in isolated muscles; leaves open whether collagen disruption impairs systolic performance in vivo or clinically.
Baicu et al. (2003) studied this question.
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