Key result
Acute and specific collagen type I degradation using purified collagenase increased diastolic tension by 20.4 +/- 8.1% (P < 0.05) and developed tension by 15.0 +/- 6.7% in rat papillary muscles.
Population
Perfused rat papillary muscles (n=6)
Comparison
Acute and specific removal of small collagen… vs Time controls (measurements before treatment)
Design
Preclinical
Authors
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Hypothesis-generating for collagen I in myocardial mechanics; animal data require human validation before any clinical consideration.
p-value: p=<0.05
Acute degradation of collagen type I in rat papillary muscle increases both diastolic and developed tension, suggesting structural roles for collagen struts in lateral load and fluid balance.
Lamberts et al. (2004) studied Perfused rat papillary muscle (n=6). Purified collagenase type I vs. Time controls was evaluated on Diastolic tension at 95% of maximal length (p=<0.05). Acute and specific collagen type I degradation using purified collagenase increased diastolic tension by 20.4 +/- 8.1% (P < 0.05) and developed tension by 15.0 +/- 6.7% in rat papillary muscles.
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