Why the study?
Does clonidine reduce supine blood pressure and nocturnal natriuresis in patients with primary autonomic failure and supine hypertension?
Does clonidine reduce supine blood pressure and nocturnal natriuresis in patients with primary autonomic failure and supine hypertension?
Clonidine effectively reduces supine blood pressure and nocturnal natriuresis in patients with autonomic failure, though it does not improve morning orthostatic hypotension due to residual hypotensive effects.
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May support nocturnal clonidine for supine hypertension in autonomic failure; leaves open effects on morning orthostatic tolerance.
Shibao et al. (2006) studied this question.
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