Key result
Nifedipine and transdermal nitroglycerin effectively reduced nocturnal supine systolic blood pressure by a maximum of 37 mmHg and 36 mmHg respectively compared to placebo (P<0.01).
Why the study?
Do nifedipine and nitroglycerin reduce supine blood pressure in patients with autonomic failure and supine hypertension?
Population
13 patients with severe orthostatic hypotension due to autonomic failure and supine hypertension
Comparison
Nifedipine 30 mg or nitroglycerin patch 0.025 to… vs Placebo
Design
Other
Follow-up
Overnight (12 hours)
Authors
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Nifedipine or nitroglycerin may ease bedtime supine hypertension in autonomic failure; leaves open agent choice and long-term safety in larger trials.
RCT (n=13)
Do nifedipine and nitroglycerin reduce supine blood pressure in patients with autonomic failure and supine hypertension?
p-value: p=<0.01
Both nifedipine and transdermal nitroglycerin effectively control supine hypertension in autonomic failure, but nifedipine increases nighttime sodium excretion and worsens morning orthostatic hypotension.
Jordan et al. (1999) conducted an RCT in Autonomic failure with severe orthostatic hypotension and supine hypertension (n=13). Nifedipine and Nitroglycerin vs. Placebo was evaluated on Maximum decrease in nocturnal systolic blood pressure compared with placebo (p=<0.01). Nifedipine and transdermal nitroglycerin effectively reduced nocturnal supine systolic blood pressure by a maximum of 37 mmHg and 36 mmHg respectively compared to placebo (P<0.01).
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