Takotsubo cardiomyopathy susceptibility likely has a polygenic basis involving cumulative genetic variation in adrenergic signaling pathways.
Does not support genetic testing in Takotsubo yet; leaves open polygenic mechanisms for validation.
Overall, these data support genetic heterogeneity in TC susceptibility and a likely polygenic basis, conferring a cumulative effect on adrenergic pathway dysregulation in a subset of individual subjects. Study of larger cohorts and non-coding regulatory regions is warranted to define genetic risk factors for TC further.
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Goodloe et al. (2014) studied this question.
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