What question did this study set out to answer?

To determine whether early blood pressure variability within 24 hours of hospital admission predicts 90-day clinical outcomes in hypertensive acute stroke patients who did not undergo reperfusion therapy.

April 17, 2026Revista de investigaci�n Cl�nicaOpen Access

Association between early blood pressure variability and short-term outcomes in patients with hypertension and acute stroke: A prospective cohort study

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertension and acute stroke. Intervention: Higher early blood pressure variability (BPV) vs. Lower early blood pressure variability. Primary outcome: 90-day poor prognosis (based on modified Rankin scale score).

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Key result

Higher 24-hour SBP variability predicts poor 90-day prognosis in hypertensive acute stroke without reperfusion.

or 90

Why the study?

Does higher early blood pressure variability predict poor 90-day prognosis in hypertensive patients with acute stroke not receiving reperfusion therapy?

Key Points

To determine whether early blood pressure variability within 24 hours of hospital admission predicts 90-day clinical outcomes in hypertensive acute stroke patients who did not undergo reperfusion therapy.
Prospective cohort study enrolling patients presenting with acute stroke and a history of hypertension within 24 hours of onset, excluding those receiving reperfusion therapy in the primary cohort.
Monitored blood pressure for 24 hours after admission to calculate systolic standard deviation (SBP-SD), coefficient of variation (SBP-CV), and average real variation (ARV).
Evaluated functional outcomes at 90 days using the modified Rankin Scale (mRS) and analyzed associations using multivariate logistic regression.
Higher SBP-SD and SBP-CV independently predicted poor 90-day functional prognosis, with the predictive model displaying good discriminant ability.
In an exploratory subgroup receiving reperfusion therapy (n=18), patients exhibited higher blood pressure variability levels and achieved a lower rate of good functional prognosis (22.2%).

Study Design

Type

Cohort

Structured PICO

Does higher early blood pressure variability predict poor 90-day prognosis in hypertensive patients with acute stroke not receiving reperfusion therapy?

Population

Hypertensive patients with acute stroke within 24 hours of onset who did not receive reperfusion therapy, followed for 90 days.

Exposure

Higher early systolic blood pressure variability (SBP-SD, SBP-CV, ARV) monitored within 24h after admission.

Comparator

Lower early systolic blood pressure variability.

Outcome

90-day prognosis classified as good or poor according to the modified Rankin scale (mRS) score.hard clinical

Higher early systolic blood pressure variability is an independent predictor of poor 90-day outcomes in hypertensive patients with acute stroke not undergoing reperfusion therapy.

Discussion

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Implication

May warrant closer BPV monitoring in acute hypertensive stroke; hypothesis-generating for trials targeting variability reduction.

Cite This Study

Li et al. (2026) conducted a cohort in Hypertension and acute stroke. Higher early blood pressure variability (BPV) vs. Lower early blood pressure variability was evaluated on 90-day poor prognosis (based on modified Rankin scale score). Higher systolic blood pressure variability within 24 hours of admission was an independent predictor of poor 90-day prognosis in hypertensive patients with acute stroke.

synapsesocial.com/papers/69e1cd6f5cdc762e9d856eb9 https://doi.org/10.1016/j.ric.2026.100039

Topics

Hypertension management

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Association between early blood pressure variability and short-term outcomes in patients with hypertension and acute stroke: A prospective cohort study

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Topics

Association between early blood pressure variability and short-term outcomes in patients with hypertension and acute stroke: A prospective cohort study

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider