Impaired myocardial contractility, but not left ventricular end-systolic stiffness, was associated with increased age-adjusted mortality in patients with heart failure and preserved ejection fraction.
Observational (n=1,580)
Progression from hypertensive heart disease to HFpEF is associated with impaired myocardial contractility, which predicts increased mortality.
1) Compare left ventricular (LV) systolic stiffness and contractility in normal subjects, hypertensives without heart failure, and patients with heart failure and preserved ejection fraction (HFpEF); and 2) Determine whether LV systolic stiffness or myocardial contractility are associated with mortality in HFpEF. Arterial load is increased in hypertension and is matched by increased end-systolic LV stiffness (ventricular-arterial coupling). Increased end-systolic LV stiffness may be mediated by enhanced myocardial contractility or processes which increase passive myocardial stiffness. Healthy controls (n=617), hypertensives (No HF, n=719) and patients with HFpEF (n=244, 96% hypertensive) underwent echo-Doppler characterization of arterial (Ea) and LV end-systolic (Ees) stiffness (elastance), ventricular-arterial coupling (Ea/Ees ratio), chamber-level and myocardial contractility (stress-corrected midwall shortening). Ea and Ees were similarly elevated in hypertensives with or without HFpEF compared with controls, but ventricular-arterial coupling was similar across groups. In hypertensives, elevated Ees was associated with enhanced chamber-level and myocardial contractility, while in HFpEF, chamber and myocardial contractility were depressed compared with both hypertensives and controls. Group differences persisted after adjusting for geometry. In HFpEF, impaired myocardial contractility (but not Ees) was associated with increased age-adjusted mortality. While arterial load is elevated and matched by increased LV systolic stiffness in hypertension with or without HFpEF, the mechanisms of systolic LV stiffening differ substantially. These data suggest that myocardial contractility increases to match arterial load in asymptomatic hypertensive heart disease, but that progression to HFpEF may be mediated by processes which simultaneously impair myocardial contractility and increase passive myocardial stiffness. Keywords: Contractility , Heart Failure , Hypertension , Pathophysiology
Borlaug et al. (2009) conducted an observational in Hypertensive heart disease and HFpEF (n=1,580). HFpEF and Hypertension vs. Healthy controls was evaluated on Left ventricular systolic stiffness, contractility, and mortality. Impaired myocardial contractility, but not left ventricular end-systolic stiffness, was associated with increased age-adjusted mortality in patients with heart failure and preserved ejection fraction.