What is the clinical evidence from this study?

Study design: Cohort. Population: Acute ST-segment elevation myocardial infarction (STEMI) (n=398). Intervention: High mean platelet volume (≥10.3 fl) vs. Low mean platelet volume (<10.3 fl). Primary outcome: No-reflow (OR 4.7, 95% CI 2.3 to 9.9, p=< 0.0001).

What question did this study set out to answer?

Determine the prognostic value of admission mean platelet volume for predicting angiographic reperfusion success and six-month mortality in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

April 30, 2026Journal of the American College of Cardiology

Mean Platelet Volume on Admission Predicts Impaired Reperfusion and Long-Term Mortality in Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Q: What are the key findings of this study?

High mean platelet volume (≥10.3 fl) on admission in STEMI patients treated with primary PCI independently predicted no-reflow (OR 4.7; 95% CI 2.3-9.9) and 6-month mortality (OR 3.2; 95% CI 1.1-9.3).

Q: What question did this study set out to answer?

Determine the prognostic value of admission mean platelet volume for predicting angiographic reperfusion success and six-month mortality in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

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Key result

High mean platelet volume in STEMI links to ~4.7-fold higher odds of no-reflow after primary PCI.

OR 4.7
95% CI 2.3 to 9.9
P<0.0001
n=398

Why the study?

No data are available for the prognostic value of admission mean platelet volume in patients with STEMI treated with primary PCI.

Does high mean platelet volume on admission predict impaired angiographic reperfusion and six-month mortality in patients with STEMI treated with primary PCI?

Population

398 consecutive patients with STEMI treated with primary PCI

Comparison

High MPV (≥10.3 fl) vs low MPV (<10.3 fl) on admission

Design

Cohort study

Follow-up

Up to six months

Authors

ZHZenon HuczekCedars-Sinai Medical Center JKJanusz KochmanPoznan University of Medical Sciences KFKrzysztof J. Filipiak‬General Cardiology

Discussion

Member takes

Implication

High mean platelet volume on admission is a strong independent predictor of impaired angiographic reperfusion and six-month mortality in STEMI patients undergoing primary PCI.

Key Points

Determine the prognostic value of admission mean platelet volume for predicting angiographic reperfusion success and six-month mortality in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Enrolled 398 consecutive patients presenting with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention.
Collected blood samples on admission prior to intervention to measure mean platelet volume, followed by clinical tracking up to six months.
Patients with high mean platelet volume (≥10.3 fl) showed significantly higher rates of no-reflow (21.2% vs. 5.5%, p < 0.0001) and six-month mortality (12.1% vs. 5.1%, p = 0.0125) compared with the low volume group (<10.3 fl).
Multivariable adjustment identified high mean platelet volume as an independent predictor of no-reflow (OR 4.7, 95% CI 2.3–9.9, p < 0.0001) and six-month mortality (OR 3.2, 95% CI 1.1–9.3, p = 0.0084).
Treatment with abciximab provided a significant reduction in mortality exclusively among patients in the high mean platelet volume cohort (OR 0.02, 95% CI 0.01–0.48, p = 0.0165).

Study Design

Type

Cohort (n=398)

Structured PICO

Does high mean platelet volume on admission predict impaired angiographic reperfusion and six-month mortality in patients with STEMI treated with primary PCI?

Population

398 consecutive patients presenting with STEMI treated with primary PCI, followed for up to six months.

Exposure

High mean platelet volume (MPV ≥10.3 fl) on admission

Comparator

Low mean platelet volume (MPV <10.3 fl) on admission

Outcome

Angiographic reperfusion (no-reflow and corrected TIMI frame count) and six-month mortalityhard clinical

Main Result

Odds Ratio: 4.7 (95% CI 2.3–9.9)

Absolute Event Rate: 21.2% vs 5.5%

p-value: p=< 0.0001

High mean platelet volume on admission is a strong independent predictor of impaired angiographic reperfusion and six-month mortality in STEMI patients undergoing primary PCI.

Cite This Study

Huczek et al. (2005) conducted a cohort in Acute ST-segment elevation myocardial infarction (STEMI) (n=398). High mean platelet volume (≥10.3 fl) vs. Low mean platelet volume (<10.3 fl) was evaluated on No-reflow (OR 4.7, 95% CI 2.3 to 9.9, p=< 0.0001). High mean platelet volume (≥10.3 fl) on admission in STEMI patients treated with primary PCI independently predicted no-reflow (OR 4.7; 95% CI 2.3-9.9) and 6-month mortality (OR 3.2; 95% CI 1.1-9.3).

synapsesocial.com/papers/69f3c74280afa71d188d3904 https://doi.org/10.1016/j.jacc.2005.03.065

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Implication

High mean platelet volume on admission is a strong independent predictor of impaired angiographic reperfusion and six-month mortality in STEMI patients undergoing primary PCI.

Mean Platelet Volume on Admission Predicts Impaired Reperfusion and Long-Term Mortality in Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Mean Platelet Volume on Admission Predicts Impaired Reperfusion and Long-Term Mortality in Acute Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider