Influence of Autonomic Nervous System Dysfunction on the Development of Type 2 Diabetes
Why the study?
Does slow heart rate recovery predict increases in insulin and glucose and the development of type 2 diabetes in healthy young adults?
Population
3,295 healthy adults aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Comparison
Slow heart rate recovery following cessation of… vs Faster heart rate recovery
Design
Cohort
Follow-up
up to 15 years
Authors
Discussion
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Member takes
Implication
HRR <42 bpm may flag higher diabetes risk in unfit adults; leaves open whether autonomic assessment refines prediction or guides prevention.
Structured PICO
Does slow heart rate recovery predict increases in insulin and glucose and the development of type 2 diabetes in healthy young adults?
P
Population
3,295 healthy adults aged 18-30 years in the Coronary Artery Risk Development in Young Adults (CARDIA) study
I
Intervention
Slow heart rate recovery (HRR) following cessation of an exercise treadmill test (e.g., quartile 1 or <42 bpm)
C
Comparator
Faster heart rate recovery (e.g., quartile 4 or >42 bpm)
O
Outcome
Increases in insulin and glucose over time and the development of type 2 diabetes (glucose ≥7 mmol/l or use of diabetes control medication) at 7-, 10-, and 15-year examinationssurrogate
Autonomic dysfunction, indicated by slow heart rate recovery, combined with poor physical fitness, is associated with early glucose dysmetabolism and an increased risk of developing type 2 diabetes.
Cite This Study
Carnethon et al. (2003) studied this question.