What question did this study set out to answer?

This research aims to identify predictors of heart failure hospitalization associated with different pacing modes in patients with sinus node dysfunction.

April 25, 2006CirculationOpen Access

Heart Failure During Cardiac Pacing

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Why the study?

Does dual-chamber (DDDR) versus ventricular (VVIR) pacing reduce heart failure hospitalization in patients with sinus node dysfunction?

Population

2,010 patients with sinus node dysfunction from the Mode Selection Trial

Comparison

Dual-chamber (DDDR) pacing vs Ventricular (VVIR) pacing

Design

Cohort

Follow-up

6 years

Authors

MSMichael O. SweeneyElectrophysiology AHAnne S. HellkampElectrophysiology

Discussion

Member takes

Implication

High VVIR pacing burden was associated with increased HF hospitalization; leaves open optimal pacing mode to minimize risk in sinus node dysfunction.

Key Points

This research aims to identify predictors of heart failure hospitalization associated with different pacing modes in patients with sinus node dysfunction.
Analyzed baseline and postimplantation variables from the Mode Selection Trial involving 2010 patients over 6 years.
Utilized a Cox model to predict heart failure hospitalization based on NYHA class and other clinical indicators.
Examined interactions between clinical predictors and pacing parameters such as cumulative ventricular pacing percentage and QRS duration.
NYHA class at baseline and follow-up significantly predicted heart failure hospitalization (HR, 3.99 for class III/IV).
Higher cumulative percent ventricular pacing increased risk (HR, 3.58 for VVIR >80%).
QRS duration and baseline ejection fraction also influenced heart failure hospitalization risk, indicating the importance of pacing management.

Structured PICO

Does dual-chamber (DDDR) versus ventricular (VVIR) pacing reduce heart failure hospitalization in patients with sinus node dysfunction?

Population

2,010 patients with sinus node dysfunction from the Mode Selection Trial

Intervention

Dual-chamber (DDDR) pacing

Comparator

Ventricular (VVIR) pacing

Outcome

Heart failure hospitalization (HFH)hard clinical

High cumulative right ventricular apical pacing increases the risk of heart failure hospitalization, particularly in patients with low ejection fraction and pre-existing heart failure.

Cite This Study

Sweeney et al. (2006) studied this question.

synapsesocial.com/papers/6a02a68798cafe0df5754da2 https://doi.org/10.1161/circulationaha.105.608356

Topics

HFrEF treatment Heart failure HFpEF management Heart failure hospitalization

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Implication

High VVIR pacing burden was associated with increased HF hospitalization; leaves open optimal pacing mode to minimize risk in sinus node dysfunction.

Heart Failure During Cardiac Pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Heart Failure During Cardiac Pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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