Key result
Mean platelet volume on admission was not a significant predictor of in-hospital mortality in patients with acute coronary syndrome complicated by cardiogenic shock.
Why the study?
Does mean platelet volume predict in-hospital mortality in patients with acute coronary syndrome complicated by cardiogenic shock?
Cohort (n=106)
No
Does mean platelet volume predict in-hospital mortality in patients with acute coronary syndrome complicated by cardiogenic shock?
Absolute Event Rate: 8.9% vs 8.93%
p-value: p=>0.05
Mean platelet volume on admission does not predict in-hospital mortality in patients with acute coronary syndrome complicated by cardiogenic shock.
Admission MPV should not inform prognosis in ACS-cardiogenic shock; leaves open identification of reliable early biomarkers in this population.
BACKGROUND: Elevated mean platelet volume (MPV) has been recently discussed as a predictor of death in patients with acute coronary syndrome (ACS), but the cut-off point of MPV in relation to poor prognosis has not been estimated so far. The aim of this study was to evaluate MPV and its prognostic value in ACS complicated by cardiogenic shock (CS). Such an analysis in patients with the most serious and fatal complication of ACS has not been performed inpreviously published research. METHODS: Fifty three patients with ACS complicated by CS (age 68.9 ± 11.4, 49% women, 92% STEMI, 55% fatal CS) and 53 age- and gender-matched patients with uncomplicated ACS as a control group (age 69.1 ± 10.6, 49% women, 92% STEMI, 0% fatal) were included in our prospective study from 2010 to 2012. All the patients underwent successful primary percutaneous coronary intervention. MPV was determined on admission (MPV1) and in consecutive two days of hospitalization (MPV2, MPV3). The blood sample was analyzed immediately after collection in EDTA tubes using an automatic blood counter. RESULTS: MPV1 was similar in both groups (8.91 ± 1.11 fl vs. 8.57 ± 0.74 fl, NS). Furthermore, there were no statistically significant differences in MPV value in fatal and nonfatal CS(8.90 ± 1.18 fl vs. 8.93 ± 1.05 fl, NS). CONCLUSIONS: The above results suggest that MPV cannot be considered a predictor of poor in-hospital outcome in patients with ACS complicated by cardiogenic shock.
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Supeł et al. (2013) conducted a cohort in Acute coronary syndrome complicated by cardiogenic shock (n=106). Mean platelet volume (MPV) measurement vs. Uncomplicated ACS was evaluated on Mean platelet volume on admission (MPV1) in fatal vs non-fatal cardiogenic shock (p=>0.05). Mean platelet volume on admission was not a significant predictor of in-hospital mortality in patients with acute coronary syndrome complicated by cardiogenic shock.
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