April 1, 1992Journal of Cardiovascular Pharmacology
Mechanism of Nitrate-Induced Improvement on Arterial Compliance Depends on Vascular Territory
Key result
Acute administration of isosorbide dinitrate 20 mg significantly increased cross-sectional compliance in the common carotid, brachial, and common femoral arteries compared to placebo.
Why the study?
Does isosorbide dinitrate improve arterial compliance across different vascular territories in untreated hypertensive patients?
Population
20 untreated patients with essential hypertension
Comparison
Isosorbide dinitrate 20 mg vs Placebo
Design
RCT, randomized, parallel study, double-blind, placebo-controlled
Follow-up
acute
Authors
Discussion
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Implication
Supports acute nitrate use for compliance in untreated hypertension; extends RCT evidence across carotid, brachial, and femoral territories.
Key Points
- This study aims to explore how nitrates affect arterial compliance across different vascular territories in hypertensive individuals.
- Randomized, placebo-controlled, double-blind trial involving 20 untreated hypertensive patients,
- Administration of isosorbide dinitrate (20 mg) and measurements of arterial diameters and compliance using a pulsed ultrasound echo-tracking system.
- Comparison of measures before and during treatment to assess changes in blood pressure and arterial compliance.
- During isosorbide dinitrate therapy, blood pressure decreased significantly, and cross-sectional compliance increased in the common carotid artery, brachial artery, and common femoral artery.
- Internal diameter increase was observed in the common carotid artery, while distensibility coefficient increased in the brachial artery.
- The augmentation index of the common carotid artery distension waveform was significantly reduced during treatment, indicating less wave reflection.
Study Design
Type
RCT (n=20)
Blinding
Double-blind
Randomization
parallel
Structured PICO
Does isosorbide dinitrate improve arterial compliance across different vascular territories in untreated hypertensive patients?
P
Population
20 untreated patients with essential hypertension
I
Intervention
Isosorbide dinitrate 20 mg
C
Comparator
Placebo
O
Outcome
Internal diastolic diameter and stroke change in diameter of the common carotid artery (CCA), the femoral artery, and the brachial artery (BA)surrogate
Acute administration of isosorbide dinitrate improves arterial compliance in hypertensive patients, with the mechanism of improvement varying depending on the specific vascular territory.
Cite This Study
Laurent et al. (1992) conducted an RCT in essential hypertension (n=20). isosorbide dinitrate vs. placebo was evaluated on cross-sectional compliance of the common carotid artery, brachial artery, and common femoral artery. Acute administration of isosorbide dinitrate 20 mg significantly increased cross-sectional compliance in the common carotid, brachial, and common femoral arteries compared to placebo.