Key result
Isosorbide-5-mononitrate significantly decreased carotid-femoral pulse wave velocity at 2 and 4 weeks compared to baseline (p<0.05) in patients with essential hypertension.
Why the study?
Does isosorbide-5-mononitrate improve large artery distensibility in patients with essential hypertension?
Does isosorbide-5-mononitrate improve large artery distensibility in patients with essential hypertension?
p-value: p=<0.05
Isosorbide-5-mononitrate added to standard therapy improves large arterial distensibility in hypertensive patients independent of blood pressure changes.
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May support arterial stiffness benefits independent of BP; hypothesis-generating and requires RCTs before practice change.
Wang et al. (2001) studied essential hypertension (n=17). isosorbide-5-mononitrate (IS-5-MN) vs. baseline was evaluated on carotid-femoral pulse wave velocity (PWV) (p=<0.05). Isosorbide-5-mononitrate significantly decreased carotid-femoral pulse wave velocity at 2 and 4 weeks compared to baseline (p<0.05) in patients with essential hypertension.
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