Key result
Immunohistochemical analysis revealed that antibodies against Arg 101-Tyr 126 ANF strongly visualized granulated cardiocytes in rat and mouse atria, with weaker reactions in other mammals.
This preclinical study demonstrates species-specific differences in the localization and immunoreactivity of synthetic ANF fragments in the heart.
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Species-specific ANF patterns warrant caution extrapolating rodent data; leaves open cross-species validation needs.
Chapeau et al. (1985) studied Localization of atrial natriuretic factor. Antibodies against synthetic fragments of ANF (Arg 101-Tyr 126 and Leu 94-Arg 109) was evaluated on Localization of immunoreactive synthetic ANF. Immunohistochemical analysis revealed that antibodies against Arg 101-Tyr 126 ANF strongly visualized granulated cardiocytes in rat and mouse atria, with weaker reactions in other mammals.
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