Key result
Immunohistochemical analysis revealed that antibodies against Arg 101-Tyr 126 ANF strongly visualized granulated cardiocytes in rat and mouse atria, with weaker reactions in other mammals.
Population
Hearts of mammals and nonmammalian vertebrates
Design
Preclinical
Authors
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Species-specific ANF patterns warrant caution extrapolating rodent data; leaves open cross-species validation needs.
This preclinical study demonstrates species-specific differences in the localization and immunoreactivity of synthetic ANF fragments in the heart.
Chapeau et al. (1985) studied Localization of atrial natriuretic factor. Antibodies against synthetic fragments of ANF (Arg 101-Tyr 126 and Leu 94-Arg 109) was evaluated on Localization of immunoreactive synthetic ANF. Immunohistochemical analysis revealed that antibodies against Arg 101-Tyr 126 ANF strongly visualized granulated cardiocytes in rat and mouse atria, with weaker reactions in other mammals.
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