Key result
Chronically infarcted spontaneously hypertensive rats exhibited significantly reduced left ventricular myocardial systolic function compared to normotensive controls (P<0.05).
Why the study?
Does chronic myocardial infarction induce greater myocardial systolic dysfunction in hypertensive rats compared to normotensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Ligation of the left anterior descending… vs Sham operations (SHR-Sham and WKY-Sham)
Design
Preclinical
Follow-up
6 to 7 months
Authors
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Hypertension may worsen post-MI LV systolic function in viable myocardium; leaves open translation to clinical HF.
Does chronic myocardial infarction induce greater myocardial systolic dysfunction in hypertensive rats compared to normotensive rats?
p-value: p=<0.05
Chronic myocardial infarction in hypertensive rats leads to myocardial dysfunction in viable noninfarcted tissue and reduced cardiac adrenergic inotropic reserve, independent of excessive chamber dilatation or cell death.
Norton et al. (2007) studied Myocardial infarction in hypertension. Myocardial infarction (LAD ligation) in hypertensive rats vs. Myocardial infarction in normotensive rats and sham operations was evaluated on Left ventricular myocardial systolic function (percent shortening of noninfarcted lateral wall and percent thickening of posterior wall) (p=<0.05). Chronically infarcted spontaneously hypertensive rats exhibited significantly reduced left ventricular myocardial systolic function compared to normotensive controls (P<0.05).
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