March 15, 2018Journal of Cardiovascular Electrophysiology
Late potentials abolition reduces ventricular tachycardia recurrence after ablation especially in higher‐risk patients with a chronic total occlusion in an infarct‐related artery
Key result
Late potentials abolition is linked to ~63% lower VT recurrence in patients with infarct-related CTO.
- P=0.005
- n=84
Why the study?
Does late potentials abolition reduce ventricular tachycardia recurrence in patients with prior myocardial infarction undergoing VT ablation, particularly those with an infarct-related artery chronic total occlusion?
Population
84 patients with prior myocardial infarction and clinical ventricular tachycardia, referred for VT ablation…
Comparison
Late potentials abolition during substrate… vs No late potentials abolition
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support LP targeting in IRA-CTO VT ablation; hypothesis-generating and requires randomized confirmation.
Study Design
Type
Observational (n=84)
Multicenter
No
Structured PICO
Does late potentials abolition reduce ventricular tachycardia recurrence in patients with prior myocardial infarction undergoing VT ablation, particularly those with an infarct-related artery chronic total occlusion?
P
Population
84 patients with prior myocardial infarction and clinical ventricular tachycardia (VT), referred for VT ablation at San Raffaele Hospital between 2010 and June 2013, who had a coronary diagnostic angiography (without revascularization) performed during the index hospitalization.
I
Intervention
Late potentials (LP) abolition during substrate ablation of ventricular tachycardia
C
Comparator
No late potentials abolition
O
Outcome
Ventricular tachycardia (VT) recurrence after ablationhard clinical
Main Result
Absolute Event Rate: 24% vs 65%
p-value: p=0.005
Late potentials abolition during VT ablation significantly reduces VT recurrence, particularly in high-risk patients with a chronic total occlusion in an infarct-related artery.
Cite This Study
Marco et al. (2018) conducted an observational in Prior myocardial infarction and clinical ventricular tachycardia (n=84). Late potentials (LP) abolition vs. No LP abolition was evaluated on Ventricular tachycardia (VT) recurrence after ablation (p=0.005). Late potentials abolition significantly reduced ventricular tachycardia recurrence compared to no abolition among high-risk patients with an infarct-related artery CTO (24% vs. 65%, P=0.005).