Key result
Narrower pre-implant QRS and moderate-to-severe MR at six months independently predict CRT non-response.
Why the study?
Although LV reverse remodeling by CRT improves prognosis in heart failure patients, the time course of CRT response remains poorly characterized.
What are the predictors of late response and non-response to cardiac resynchronization therapy in heart failure patients?
Population
99 HF patients who received a CRT device at a single center
Comparison
Early responders vs late responders vs non-responders
Design
Single-center retrospective study
Authors
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May flag likely CRT non-responders; leaves open prospective validation before changing selection.
Observational (n=99)
No
What are the predictors of late response and non-response to cardiac resynchronization therapy in heart failure patients?
Moderate to severe mitral regurgitation at six months and narrower baseline QRS duration predict failure to respond to CRT, even late after implantation.
T et al. (2022) conducted an observational in Heart failure (n=99). Cardiac resynchronization therapy (CRT) vs. Non-responders was evaluated on Predictors of non-response to CRT. Narrower QRS duration before implantation (p=0.046) and moderate to severe mitral regurgitation at 6 months (p=0.035) independently predicted non-response to cardiac resynchronization therapy.
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