Key result
Delayed CRT responders match early responder prognosis, though longer HF history and suboptimal leads predict delay.
Why the study?
Clinical outcomes and mechanisms of delayed responses to cardiac resynchronization therapy remained unclear.
Do delayed responders to cardiac resynchronization therapy have similar long-term clinical outcomes compared to early responders?
Population
110 patients who underwent CRT implantation
Comparison
Early response vs delayed response vs non-response
Design
Retrospective study
Follow-up
10.3 ± 0.5 years
Authors
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Delayed CRT responders may have comparable long-term outcomes; leaves open whether earlier intervention or lead optimization improves response in prospective studies.
Cohort (n=110)
Do delayed responders to cardiac resynchronization therapy have similar long-term clinical outcomes compared to early responders?
Effect estimate: OR 1.126 (95% CI 1.036-1.222)
p-value: p=0.005
Patients who exhibit a delayed echocardiographic response to CRT achieve similar long-term survival and freedom from heart failure hospitalization as early responders.
Tsurumi et al. (2023) conducted a cohort in Heart failure requiring cardiac resynchronization therapy (n=110). Cardiac resynchronization therapy (delayed vs early response) vs. Early response or non-response was evaluated on Predictors of delayed response to CRT compared with early response (longer duration between initial HF hospitalization and CRT) (OR 1.126, 95% CI 1.036-1.222, p=0.005). Delayed and early responders to CRT had similar long-term prognosis, while a longer history of heart failure (OR 1.126; 95% CI 1.036-1.222) and suboptimal LV lead position predicted delayed response.
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