Key result
Captopril therapy significantly improved exercise time (mean increase 82 s vs 35 s) and NYHA class (41% vs 22%) compared with placebo in patients with mild to moderate heart failure.
Why the study?
Does captopril improve exercise time and symptoms compared to digoxin or placebo in patients with mild to moderate heart failure on maintenance diuretics?
Population
Patients with mild to moderate heart failure receiving maintenance diuretic therapy
Comparison
Captopril treatment vs Digoxin treatment or placebo
Design
RCT, double-blind, placebo-controlled
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Supports captopril in mild-moderate HF on diuretics; extends ACEI evidence to less severe disease.
RCT
Double-blind
Yes
Does captopril improve exercise time and symptoms compared to digoxin or placebo in patients with mild to moderate heart failure on maintenance diuretics?
Absolute Event Rate: 41% vs 22%
Captopril is an effective alternative to digoxin for improving exercise capacity and clinical status in patients with mild to moderate heart failure receiving diuretic therapy.
A 1988 study conducted an RCT in Mild to moderate heart failure. Captopril vs. Digoxin and placebo was evaluated on Improved New York Heart Association class. Captopril therapy significantly improved exercise time (mean increase 82 s vs 35 s) and NYHA class (41% vs 22%) compared with placebo in patients with mild to moderate heart failure.
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