Key result
Captopril administration for 7 days significantly increased peak serum digoxin concentration from 1.7 to 2.7 ng/ml (p=0.01) in patients with severe congestive heart failure.
Why the study?
Does captopril alter serum digoxin concentrations in patients with severe congestive heart failure?
Population
8 patients with severe (NYHA Class IV) congestive heart failure on chronic digoxin therapy (0.25 mg PO q.d.)
Comparison
Captopril 12.5 mg PO t.i.d. for 7 days vs Baseline (before captopril administration)
Design
Cohort
Follow-up
7 days
Authors
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May warrant digoxin monitoring with captopril in severe HF; leaves open confirmation and practice change in RCTs.
Does captopril alter serum digoxin concentrations in patients with severe congestive heart failure?
Absolute Event Rate: 2.7% vs 1.7%
p-value: p=0.01
Concomitant administration of captopril with digoxin significantly increases serum digoxin concentrations in patients with severe heart failure, highlighting a clinically relevant pharmacokinetic interaction.
Kırımlı et al. (2001) studied severe congestive heart failure (n=8). Captopril vs. Baseline (before captopril administration) was evaluated on Peak serum concentration of digoxin (Cmax) (p=0.01). Captopril administration for 7 days significantly increased peak serum digoxin concentration from 1.7 to 2.7 ng/ml (p=0.01) in patients with severe congestive heart failure.
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