Enalapril reduced blood pressure and caused cardiac regression in both hypertensive and normotensive Dahl rats, whereas hydrochlorothiazide was effective only in Dahl sensitive rats on a high salt diet.
Does enalapril or hydrochlorothiazide reduce blood pressure and reverse myocardial hypertrophy in Dahl rats on high or low salt diets?
Enalapril is effective at reducing blood pressure and reversing cardiac hypertrophy in both salt-sensitive and salt-resistant hypertensive rat models, whereas hydrochlorothiazide is only effective in salt-sensitive models on a high salt diet.
p-value: p=<0.001
Enalapril maleate (MK 421), and hydrochlorothiazide were used to evaluate the control of hypertension and reversal of myocardial hypertrophy in Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl) or a low salt (0.4% NaCl) diet. Groups of six-week-old male DS and DR rats were treated with enalapril (15-100 mg/kg/day) in drinking water for eight weeks. Additional comparable groups of DS and DR were also treated with hydrochlorothiazide (60-400 mg/kg/day). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and heart weight/body weight (Hwt/Bwt) ratio were determined. We observed significant reduction in Hwt/Bwt ratio (P less than 0.001) along with control of SBP and DBP in the DS given a high salt diet treated with either enalapril or hydrochlorothiazide. However, in the DR given a high salt diet, cardiac regression (Hwt/Bwt ratio, P less than 0.05), SBP and DBP (P less than 0.01) reduction were seen only with enalapril. Similarly, cardiac regression (Hwt/Bwt ratio, P less than 0.05) was observed along with reduction of SBP and DBP (P less than 0.001) in the DS given a low salt diet and DR given enalapril. These data indicate that enalapril reduced SBP and DBP in association with cardiac regression in hypertensive and normotensive rats. In contrast, hydrochlorothiazide only reduced SBP, DBP and caused cardiac reversal (Hwt/Bwt ratio) in DS placed on a high salt diet.
Sharma et al. (Sat,) conducted a other in Hypertension and myocardial hypertrophy. Enalapril maleate vs. Hydrochlorothiazide was evaluated on Systolic blood pressure, diastolic blood pressure, heart rate, and heart weight/body weight ratio (p=<0.001). Enalapril reduced blood pressure and caused cardiac regression in both hypertensive and normotensive Dahl rats, whereas hydrochlorothiazide was effective only in Dahl sensitive rats on a high salt diet.