Why the study?
Does enalapril with or without hydrochlorothiazide reduce systolic blood pressure in Dahl salt-sensitive and salt-resistant rats?
Population
Conscious Dahl salt-sensitive and salt-resistant rats maintained on a high salt and a normal salt diet.
Design
Preclinical
Follow-up
7 weeks
Authors
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Does not alter clinical hypertension practice; leaves open mechanisms beyond ACE inhibition in salt-sensitive models.
Does enalapril with or without hydrochlorothiazide reduce systolic blood pressure in Dahl salt-sensitive and salt-resistant rats?
Enalapril significantly reduces systolic blood pressure in both salt-sensitive and salt-resistant rats, suggesting mechanisms of action beyond ACE inhibition.
Sharma et al. (1984) studied this question.
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