Key result
Enalapril and hydrochlorothiazide reduce BP and LV mass in rats, independent of pressure afterload.
Why the study?
Does enalapril or hydrochlorothiazide reduce blood pressure and left ventricular mass in Dahl sensitive and resistant rats on high or low salt diets?
Population
Dahl sensitive (DS) and Dahl resistant (DR) rats given either a high (8% NaCl) or a low (0.4% NaCl) salt diet
Design
Preclinical
Authors
Loading...
Does not support changes in clinical hypertension management; leaves open translation of non-hemodynamic LVH mechanisms from Dahl rat models.
Does enalapril or hydrochlorothiazide reduce blood pressure and left ventricular mass in Dahl sensitive and resistant rats on high or low salt diets?
The dissociation between blood pressure reduction and left ventricular mass regression suggests that pressure afterload is not the sole driver of hypertensive cardiac hypertrophy.
Fernandez et al. (1984) studied Hypertensive left ventricular hypertrophy. Enalapril maleate (MK421) and hydrochlorothiazide (HTZ) was evaluated on Systolic blood pressure, diastolic blood pressure, heart rate, left ventricular weight/body weight ratio. Enalapril and hydrochlorothiazide reduced blood pressure and left ventricular mass in Dahl sensitive rats on a high salt diet, showing pressure afterload is not the only factor in hypertrophy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: