Why the study?
Does shear stress suppress angiotensin-converting enzyme (ACE) expression and activity in endothelial cells?
Population
Bovine pulmonary artery endothelial cells, rabbit aortic endothelial cell line stably transfected with rat…
Comparison
Shear stress vs Unsheared cells or normal flow conditions
Design
Preclinical
Follow-up
up to 18 hours (in vitro)
Authors
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Shear stress may regulate endothelial ACE; leaves open human relevance for flow-mediated vascular protection.
Does shear stress suppress angiotensin-converting enzyme (ACE) expression and activity in endothelial cells?
Elevations in shear stress alter endothelial cell function by suppressing ACE gene and protein expression both in vitro and in vivo.
Rieder et al. (1997) studied this question.
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