Key result
Alpha 2-adrenoceptor blockade significantly reduced the constrictor response to EDNO blockade after haemorrhage (P<0.01), indicating catecholamines trigger EDNO release via these receptors.
Population
Sympathectomized vascular bed of cat skeletal muscle subjected to 35% blood loss
Comparison
Selective alpha 2-adrenoceptor blockade with… vs EDNO blockade in the absence of alpha…
Design
Preclinical
Authors
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Hypothesis-generating for alpha2-EDNO feedback in animal hemorrhage; leaves open clinical relevance in human shock.
p-value: p=<0.01
Blood-borne catecholamines trigger increased EDNO release via endothelial alpha 2-adrenoceptors during acute hemorrhage, providing a negative feedback mechanism to control vascular tone.
EKELUND et al. (1998) studied Acute haemorrhage. Alpha 2-adrenoceptor blockade (idazoxan) and EDNO blockade (L-NAME) vs. Absence of alpha 2-adrenoceptor blockade was evaluated on Constrictor response to EDNO blockade (p=<0.01). Alpha 2-adrenoceptor blockade significantly reduced the constrictor response to EDNO blockade after haemorrhage (P<0.01), indicating catecholamines trigger EDNO release via these receptors.
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