Key result
Postdilation after PCI in ACS tends to reduce MACE but increases all-cause death ~49%.
Why the study?
The effect of postdilation after percutaneous coronary intervention in patients with acute coronary syndrome remains controversial.
Does postdilation after percutaneous coronary intervention reduce major adverse cardiovascular events in patients with acute coronary syndrome?
Population
11 studies of patients with acute coronary syndrome undergoing PCI
Comparison
Postdilation vs non-postdilation
Design
Systematic review and meta-analysis
Authors
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Postdilation after PCI in ACS warrants caution due to higher all-cause death; leaves open net benefit on MACE pending randomized trials.
Meta-Analysis
Does postdilation after percutaneous coronary intervention reduce major adverse cardiovascular events in patients with acute coronary syndrome?
Effect estimate: OR 0.67 (95% CI 0.45-1.00)
p-value: p=0.05
In patients with acute coronary syndrome undergoing percutaneous coronary intervention, postdilation may tend to reduce MACE but is associated with a significant increase in all-cause death.
Li et al. (2021) conducted a meta-analysis in Acute coronary syndrome. Postdilation vs. Non-postdilation was evaluated on Major adverse cardiovascular events (MACE) (OR 0.67, 95% CI 0.45-1.00, p=0.05). Postdilation after percutaneous coronary intervention in acute coronary syndrome tended to decrease MACE (OR 0.67; 95% CI 0.45-1.00; P=0.05) but increased all-cause death (OR 1.49; 95% CI 1.05-2.12).
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