Key result
Antihypertensive regimens that reduce blood pressure by vasodilation, rather than by lowering cardiac output, consistently normalize resistance vessel structure in essential hypertension.
Why the study?
Does antihypertensive therapy causing vasodilation improve resistance vessel structure better than therapy lowering cardiac output in essential hypertension?
Population
Patients with essential hypertension and animal models
Comparison
Antihypertensive therapy causing vasodilation vs Antihypertensive therapy lowering cardiac output
Design
Review
Authors
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May support vasodilator-based regimens for vessel normalization; hypothesis-generating pending randomized outcome trials.
Does antihypertensive therapy causing vasodilation improve resistance vessel structure better than therapy lowering cardiac output in essential hypertension?
Antihypertensive treatments that reduce blood pressure via vasodilation are more effective at normalizing resistance vessel structure than those that lower cardiac output.
Christensen et al. (2001) conducted a review in Essential hypertension. Antihypertensive therapy (vasodilation) vs. Antihypertensive therapy (lowering cardiac output) was evaluated on Change in resistance vessel structure. Antihypertensive regimens that reduce blood pressure by vasodilation, rather than by lowering cardiac output, consistently normalize resistance vessel structure in essential hypertension.
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