What does this research mean for the field?

In hypertensive patients treated with vasodilators, angiotensin is a major determinant of blood pressure, and the hypotensive effect of beta-blockers like propranolol is driven by the suppression of renin release, indicating that the angiotensin feedback-suppression mechanism is located proximal to beta-adrenergic receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 5, 1975New England Journal of Medicine

Renin Release, Saralasin and the Vasodilator-Beta-Blocker Drug Interaction in Man

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Why the study?

Does saralasin administration reveal the role of the renin-angiotensin system in the vasodilator-beta-blocker drug interaction in hypertensive patients?

Population

7 hypertensive subjects using minoxidil and propranolol

Comparison

Saralasin administration following withdrawal of… vs Saralasin administration while on propranolol

Design

Case_series

Authors

WPWilliam A. PettingerThe University of Texas Southwestern Medical Center HMHelen C. MitchellUnited States Military Academy

Discussion

Member takes

Implication

Case observations support renin-angiotensin mediation in vasodilator-beta blocker synergy; leaves open generalizability and clinical testing.

Structured PICO

Does saralasin administration reveal the role of the renin-angiotensin system in the vasodilator-beta-blocker drug interaction in hypertensive patients?

Population

7 hypertensive subjects using minoxidil and propranolol

Intervention

Saralasin (an angiotensin antagonist) administration following withdrawal of propranolol

Comparator

Saralasin administration while on propranolol (within-subject comparison)

Outcome

Blood pressure and plasma renin activitysurrogate

Propranolol lowers blood pressure in vasodilator-treated hypertensive patients by suppressing renin release, demonstrating that angiotensin is a major determinant of blood pressure in this setting.

Cite This Study

Pettinger et al. (1975) studied this question.

synapsesocial.com/papers/6a158dfbd64fa333899fce1c https://doi.org/10.1056/nejm197506052922304

Topics

Hypertension management

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Implication

Case observations support renin-angiotensin mediation in vasodilator-beta blocker synergy; leaves open generalizability and clinical testing.

Renin Release, Saralasin and the Vasodilator-Beta-Blocker Drug Interaction in Man

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Renin Release, Saralasin and the Vasodilator-Beta-Blocker Drug Interaction in Man

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider