Why the study?
It was unknown whether CRT with biventricular pacing reduces the risk of AF development, and predictors of AF occurrence needed identification.
Does cardiac resynchronization therapy with biventricular pacing reduce the risk of atrial fibrillation in patients with systolic heart failure?
Population
126 patients with symptomatic systolic HF eligible for CRT with biventricular pacing
Comparison
Clinical responders vs non-responders to CRT
Design
Prospective study
Follow-up
24 months
Key result
Cardiac resynchronization therapy was associated with an increase in atrial fibrillation frequency from 52.4% to 56.9% at 2 years (p<0.001), with non-response to CRT as a strong predictor.
Authors
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AF frequency rose after CRT in this cohort; leaves open whether biventricular pacing affects arrhythmia risk in systolic HF.
Cohort (n=126)
Does cardiac resynchronization therapy with biventricular pacing reduce the risk of atrial fibrillation in patients with systolic heart failure?
Absolute Event Rate: 56.9% vs 52.4%
p-value: p=<0.001
In patients with systolic heart failure receiving CRT, the frequency of AF increased over 24 months, with non-response to CRT, larger LA diameter, and posterolateral CS lead position identified as significant predictors of AF occurrence.
Grbović et al. (2023) conducted a cohort in Systolic heart failure (n=126). Cardiac resynchronization therapy (CRT) with biventricular pacing vs. Baseline was evaluated on Frequency of atrial fibrillation (AF) occurrence (p=<0.001). Cardiac resynchronization therapy was associated with an increase in atrial fibrillation frequency from 52.4% to 56.9% at 2 years (p<0.001), with non-response to CRT as a strong predictor.
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