Key result
Injection of controlled volumes of saline into the left atrium of anaesthetized dogs demonstrated a linear relationship between the injected volume and the change in V wave amplitude.
Population
Thoracotomized dogs anaesthetized with sodium pentobarbitone and ventilated artificially
Design
Preclinical
Authors
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Animal data on LA V-wave linearity leave open translation to human pressure monitoring or HF phenotyping.
In an anesthetized dog model, the pressure-volume relationship in the left atrium demonstrates linearity, even at small volumes.
M. Fahim (1978) studied Normal physiology (anaesthetized dogs). Controlled volumes of saline injected into the left atrium was evaluated on Change in the amplitude of the V wave. Injection of controlled volumes of saline into the left atrium of anaesthetized dogs demonstrated a linear relationship between the injected volume and the change in V wave amplitude.
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