Key result
Diastolic ventricular hypertension produced a homogenous increase of diastolic flow across the left ventricular wall with intact autoregulation, but decreased subendocardial flow when abolished.
Why the study?
How does diastolic ventricular hypertension affect regional diastolic coronary flow in a canine model?
Population
Canine heart model paced at a constant rate and perfused only during diastole with a constant coronary…
Comparison
Diastolic ventricular hypertension vs Intact versus abolished metabolic coronary…
Design
Preclinical
Authors
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May compromise subendocardial perfusion if autoregulation impaired; extends mechanistic insights but leaves open human translation.
How does diastolic ventricular hypertension affect regional diastolic coronary flow in a canine model?
Diastolic ventricular hypertension produces higher subendocardial than subepicardial mechanical resistance to diastolic coronary flow, which can compromise subendocardial perfusion if metabolic autoregulation is impaired.
R Domenech (1978) studied Diastolic ventricular hypertension. Diastolic ventricular hypertension vs. Intact vs abolished metabolic coronary autoregulation was evaluated on Regional diastolic coronary flow. Diastolic ventricular hypertension produced a homogenous increase of diastolic flow across the left ventricular wall with intact autoregulation, but decreased subendocardial flow when abolished.
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