Key result
Doxorubicin induces dose-limiting cardiotoxicity that is primarily driven by increased oxidative stress.
Why the study?
Does Methanolic Extract of Thevetia Peruviana Leaves reduce doxorubicin induced cardio toxicity in Wistar rats?
Does Methanolic Extract of Thevetia Peruviana Leaves reduce doxorubicin induced cardio toxicity in Wistar rats?
May support Thevetia peruviana extract testing in doxorubicin models; leaves open human translation.
Doxorubicin is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumors. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity.
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Samiya et al. (2018) studied this question. Doxorubicin induces dose-limiting cardiotoxicity that is primarily driven by increased oxidative stress.
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