Initial abnormal depolarization in acute myocardial infarction. Relations with left ventricular function.

Q: What does this research mean for the field?

The integral value of initial abnormal depolarization (IAD) derived from spatial magnitude electrocardiography strongly correlates with left ventricular ejection fraction and wall motion abnormalities, serving as a reliable indicator of left ventricular systolic function in acute myocardial infarction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Shigeo Horinaka

doi:10.5105/jse.10.21

January 1, 1990Japanese Journal of ElectrocardiologyOpen Access

Initial abnormal depolarization in acute myocardial infarction. Relations with left ventricular function.

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Why the study?

Does the Initial Abnormal Depolarization (IAD) value correlate with left ventricular systolic function in patients with acute myocardial infarction?

Structured PICO

Does the Initial Abnormal Depolarization (IAD) value correlate with left ventricular systolic function in patients with acute myocardial infarction?

P

Population

60 subjects in Japan, including 28 patients with first acute myocardial infarction (13 anterior, 15 inferior; no conduction abnormalities, no PTCR/PTCA), 20 healthy controls, and 12 patients with chest pain syndrome (normal coronary angiography).

I

Intervention

Measurement of Initial Abnormal Depolarization (IAD) value and duration from spatial magnitude electrocardiogram (orthogonal X, Y, Z leads) at approximately 1 month post-admission.

C

Comparator

Healthy controls (for ECG parameters) and chest pain syndrome patients with normal coronary arteries (for LV function parameters).

O

Outcome

Correlation between IAD value and left ventricular ejection fraction (LVEF) as well as the number of segments with reduced wall motion assessed by left ventricular angiography.surrogate

Limitations

Exclusion of mild wall motion abnormalities due to strict criteria
LVEF is influenced by compensatory hyperkinesis and non-infarcted region contractility
Differences in IAD measurement conditions (1000 samples/sec) compared to previous studies

Implication

The initial abnormal depolarization (IAD) value derived from spatial magnitude electrocardiography strongly correlates with left ventricular ejection fraction and wall motion abnormalities, serving as a useful non-invasive indicator of LV systolic function after acute myocardial infarction.

Abstract

急性心筋梗塞症28例と対照群20例について直交X, Y, Z誘導のQRS波を1000samples/secでA/D変換し加算平均後, 瞬時空間ベクトルの大きさを計算して空間マグニチュード心電図のQRS波 (以下空間QRS波と略) とその一次微分波形を描出した.一次微分波形より初期異常脱分極部分 (initial abnormal depolarization) の幅を求め空間QRS波の同領域の瞬時空間ベクトルの積分値 (以下IAD値と略) を算出し, 心筋梗塞群で左室造影から求めた駆出率および15度radialsystemより算出した短縮率の低下を認めた壁運動低下区域の個数との関係を検討した.IAD値は対照群1.67±0.78mV・sec (平均±SD) , 心筋梗塞群6.15±4.36 (p<0.01) であった.IAD値と駆出率にはr=-0.80, p<0.01の有意の負の相関, IAD値と壁運動低下区域個数にはr=0.92, p<0.01の有意の正相関が認められた.IAD値は急性心筋梗塞症の左室収縮機能をよく反映する指標であり, 発症後の病態評価に有用と考えられた.

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Cite This Study

Shigeo Horinaka (1990) studied this question.

synapsesocial.com/papers/6a199d07407564563bf651dd https://doi.org/10.5105/jse.10.21

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Initial abnormal depolarization in acute myocardial infarction. Relations with left ventricular function.

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Initial abnormal depolarization in acute myocardial infarction. Relations with left ventricular function.

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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